Bibliografie
Journal Article
The effect of timing of teriparatide treatment on the circadian rhythm of bone turnover in postmenopausal osteoporosis
, , , , ,
: European Journal of Endocrinology vol.164, 4 (2011), p. 643-648
: CEZ:AV0Z10750506
: NS10564, GA MZd
: intact parathyroid-hormone, serum cortisol, diurnal rhythm, growth-hormone, in-vivo, resorption, osteoprotegerin, calcium, abnormalities, osteocalcin
(eng): We hypothesized that with the administration of teriparatide (TPTD) treatment at different times, we would be able to modify the physiological circadian rhythm of bone turnover. The concentration of serum C-terminal telopeptide of collagen type I (beta CTX), serum N-terminal propeptide of procollagen type I (P1NP), serum ionized calcium (iCa), and plasma PTH were measured every 3 h over a 24 h period in 14 postmenopausal osteoporotic women (aged 72.4 +/- 9.3 years) treated with 20 mu g TPTD for long term, given at different times of the day. General linear model-repeated measurements (GLM RM) were performed to analyze the circadian rhythms as well as intergroup comparisons.
: FB